Johnson 2025 Serine Threonine Synthesis

Johnson 2025 Serine Threonine Synthesis. The challenges in the total synthesis of cyclic peptides lie in the preparation of unnatural amino acids if present and the peptide cyclization. The synthesis of threonine typically involves multiple steps, such as the strecker synthesis or reductive amination, where starting materials like aldehydes or ketones are reacted with.

Threonine also inhibits the first enzyme specific to threonine synthesis, homoserine kinase. This account focuses on our work in the development of serine/threonine ligation (stl), which originates from a chemoselective reaction between an unprotected peptide with a.